Has a startup lastly discovered one in every of meals science’s holy grails with its wholesome sugar substitute? – TechCrunch

Has a startup finally found one of food science’s holy grails with its healthy sugar substitute? – TechCrunch

Rather less than three years in the past on the Pc Science Museum in Mountain View, Calif. the founders of a younger firm hailing from Cambridge, England addressed a crowd of celebrities, buyers and entrepreneurs at Y Combinator’s August Demo Day promising a revolution in meals science.

Through the years, the occasion has turn into a comparatively low-tech, low-budget showcase for a bunch of tech buyers and billionaire trade insiders to check out early stage companies that might be their subsequent billion-dollar alternative.

Sharing the stage with different innovation-minded budding entrepreneurs the Cambridge scientists boasted of a know-how may produce a sweetener that might mimic not simply the style of sugar, however the caramelization and stickiness that makes sugar the go-to additive for the majority of roughly 74% of packaged meals which can be made with some type of sweetener. Their company, Cambridge Glycoscience  may declare an enormous slice of a market value not less than a $100 billion market, they mentioned.

Now, the corporate has a brand new identify, Supplant, and $24 million in enterprise capital financing to begin commercializing its low-cost sugar substitute comprised of the waste supplies of different crops.


The bitter historical past of the sweetest ingredient

Sugar got here into the human weight loss program roughly 10,000 years in the past as sugarcane, which is native to New Guinea and elements of Taiwan and China. Over the following 2,000 years the crop unfold from these areas to Madagascar and finally took root in India, the place it was first refined in about 500 BC.

From there, the sweetener unfold throughout the identified world. By the primary century AD Greek and Roman students have been referencing its medicinal properties and, after the Crusades, sugar consumption traveled throughout Europe by way of the Center Ages.

It was a welcome substitute from Europe’s mainstay, honey, and the early synthetic sweeteners utilized by the Romans, which contained near-lethal doses of lead.

The chilly climates of Northern Europe proved largely inhospitable to sugarcane cultivation so the foundation took root within the extra temperate South and the islands off of Europe’s southern coast.

These areas additionally grew to become residence to the primary European experiments with agricultural slavery — a byproduct of the sugar commerce, and one that might plant the seeds for the worldwide exploitation of indigenous American and African labor for hundreds of years as the economic progress of sugar manufacturing unfold to the New World.

First, European indentured servants and enslaved indigenous individuals’s powered the manufacturing of sugar within the Americas. However as native populations died off because of the introduction of European illnesses, genocidal assaults, and back-breaking labor, African slaves have been dropped at the brand new colonies to work the fields and mills to make refined sugar.

Sugar hangover

The horrors of slavery could be the most damning legacy of commercial sugar, nevertheless it’s removed from the one drawback attributable to the human longing for sweeteners.

As local weather change turns into extra of a risk, fears of increasing deforestation to meet the world’s demand — or to provide cover for other industrialization of virgin forests — have arisen because of new insurance policies in Brazil.

“Standard cane sugar is closely closely water intensive,” mentioned Supplant co-founder Tom Simmons in an interview. That’s one other drawback for the atmosphere as water turns into the following useful resource to be confused by the currents of local weather change. And species extinction presents one other big drawback too.

“The WWF primary supply for biodiversity misplaced globally is cane sugar plantations,” Simmons mentioned. “Sugar is an enormous shopper of water and in distinction, there’s large sustainability pitch for what we do.. the uncooked supplies are merchandise of the present agricultural trade.”

And the hunt for sugar substitutes within the U.S. has include associated well being prices as excessive fructose corn syrup has made its manner into tons of American merchandise. Invented in 1957, corn syrup is without doubt one of the commonest sweeteners used to interchange sugar — and one which’s thought to have extremely disastrous results on the well being of shoppers worldwide.

Using corn syrup has been linked to an increasing prevalence of diabetes, obesity, and fatty liver disease, on the planet’s inhabitants.

MELBOURNE, AUSTRALIA – APRIL 08: On this photograph illustration, merchandise containing excessive sugar ranges are on show at a grocery store on April 8, 2016 in Melbourne , Australia. The World Well being Organisation’s first international report on diabetes discovered that 422 million adults dwell with diabetes, primarily in growing nations. Australian diabetes specialists are urging the Federal Authorities to think about imposing a sugar tax to sort out the rising drawback. (Photograph by Luis Ascui/Getty Pictures)

Trying For A More healthy Substitute

As Supplant and its buyers look to take the crown because the reigning substitute for sugar, they be part of a protracted line of would-be occupants to sugar’s throne.

The primary viable, non-toxic chemically derived sugar substitute was found within the late 18th century by a German chemist. Known as saccharine it was popularized initially throughout sugar shortages attributable to the primary World Struggle and gained traction throughout the well being crazes of the sixties and seventies.

Saccharin, nonetheless accessible in pink Candy n’ Low packets and a bunch of merchandise, was succeeded by aspartame (identified commercially as Equal and current because the sugar substitute in drinks like Food plan Coke), which was supplanted by sucralose (often called Splenda).

These chemically derived sweeteners have been the usual available on the market for many years now, however with a rising push for pure — reasonably than chemical — substitutes for sugar and their failures to behave as a substitute for the entire issues that sugar can do as a meals ingredient, the demand for a greater sugar has by no means been larger.

Supplanting the competitors 

“Not all the things that we again goes to vary the world. This, at scale, does that.” mentioned Aydin Senkut, the founder and managing accomplice of Felicis Ventures, the enterprise agency that’s one in every of Supplant’s greatest backers. 

A part of what satisfied Senkut is the truth that Supplant’s sweetener has already acquired preliminary approvals within the European Union by the area’s regulatory equal of the Meals and Drug Administration. That approval not solely covers the sale of Supplant’s product as a sweetener, but additionally as a probiotic with tangible well being advantages he mentioned.

So not solely is the Supplant product arguably a greater and extra direct sugar substitute, because the founders declare, it additionally has well being advantages by way of offering elevated fiber in shoppers who use it frequently, Senkut mentioned.

“The European FDA is even stricter than the U.S. FDA,” Senkut mentioned. “[And] they acquired pre-approval for this.”

Senkut and Felicis invested in Cambridge Glycosciences nearly instantly after seeing the corporate’s presentation at Y Combinator.

“We grew to become the most important buyers at seed,” Senkut mentioned.

Its promoting factors have been the merchandise extraordinarily low glycemic index and its potential to be manufactured from waste plant fibers, which signifies that it finally could be produced at a decrease price, based on Senkut.

What’s the distinction? 

Supplant differs from its competitors in a variety of different key methods, based on firm co-founder Tom Simmons.

Whereas firms just like the Israeli startup DouxMatok or Colorado’s MycoTechnology and Wisconsin’s Sensient work on growing components from fungus or tree roots or bark that may improve the sweetness of sugars, Supplant makes use of different sugars to create its sweetener, Simmons mentioned. 

“The core distinction is that they’re working with cane sugar,” based on Simmons. “Our pitch is we make sugars from fiber so that you don’t want to make use of cane sugar.”

Simmons mentioned that these different startups have been approaching the issue from the unsuitable course. “The issue that their know-how addresses isn’t the issue the trade has,” Simmons mentioned. “It’s about texture, bulking, caramelization and crystallization… We have now a know-how that’s going to provide the similar sweetness gram for gram.”

There are six several types of calorific sugar, Simmons defined. There’s lactose, which is the sugar in milk; sucrose, which comes from sugarcane and sugar beets; maltose, present in grains like wheat and barley; fructose, the sugar in fruits and honey; glucose, which is in almost all the things, however particularly carbohydrate-laden greens, fruits, and grains; and galactose, a easy sugar that derives from the breakdown of lactose.

Simmons mentioned that his firm’s sugar substitute isn’t based mostly on one compound, however is derived from a spread of issues that come from fiber. Using fibers signifies that the physique acknowledges the compounds as fibrous and treats them the identical manner within the digestive tract, however the merchandise style and act like sugar in meals, he mentioned. “Fiber derived sugars are within the class of sugars, however should not the calorific sugars,” mentioned Simmons.

NEW YORK – DECEMBER 6: Packets of the favored sugar substitute Splenda are seen December 6, 2004 in New York Metropolis. The producer of sucralose, the important thing ingredient within the no-calorie sweetener, says demand is so excessive for the product that it won’t be able to tackle new U.S. clients till it doubles manufacturing in 2006. Splenda has been boosted by the recognition of the low-sugar Atkins weight loss program. (Photograph Illustration by Mario Tama/Getty Pictures)

Belief the method? 

Supplant’s know-how makes use of enzymes to interrupt down and fragment varied fibers. “As you begin breaking it down, it begins wanting molecularly like sucrose — like cane sugar — so it begins behaving in the same manner,” mentioned Simmons.

That is all the results of years of analysis that Simmons started at Cambridge College, he mentioned. “I arrived at Cambridge meaning to be a professor. I didn’t arrive in Cambridge intending to begin a enterprise. I used to be taken with doing science, making innovations and stuff that might attain the broader world. I at all times imagined the best manner for me to do this was to be a professor.”

In time, after receiving his doctorate and starting his post-doctoral work into the analysis that might finally flip into Supplant, Simmons realized that he needed to begin an organization. “To attempt to do one thing impactful I used to be going to have go away the college,” he mentioned. 

In some methods, Supplant operates on the intersection of all of Simmons’ pursuits in well being, vitamin, and sustainability. And he mentioned the corporate has plans to use the processing know-how throughout a spread of shopper merchandise finally, however for now the corporate stays centered on the $100 billion sugar substitute market.

“There’s a handful of various core underlying scientific approaches in numerous areas,” he mentioned. The form of issues that go into private care and homecare. These chemical substances. An enormous drive within the trade is for each much less harsh and harsh chemical substances in shampoos but additionally to take action in a manner that’s sustainable. That’s made kind a sustainable supply but additionally biodegradable.”

Subsequent steps 

With the cash that the corporate has now raised from buyers together with Felicis, Soma Capital, and Y Combinator, Supplant is now going to show its merchandise in a couple of very focused take a look at runs. The primary is a giant launch with a celeb chef, which Simmons teased, however didn’t elaborate on.

Senkut mentioned that the corporate’s roll out can be just like the methods by which Inconceivable Meals went to market. Starting with a couple of trial runs in larger finish eating places and foodstuffs earlier than attempting to make a run at a mass shopper market.

The feedstocks for Supplant’s sugar substitute come from sugar cane bagasse, wheat and rice husks, and the processing tools comes from the brewing trade. That’s going to be a profit as the corporate appears to construct out an workplace within the U.S. because it establishes a foothold for a bigger manufacturing presence down the road.

“We’re taking identified science and making use of it within the meals trade the place we all know that it has worth,” Simmons mentioned. “We’re not inventing any model new enzymes and every a part of the method — none of it on their very own are new. The invention that these sugars work effectively and might exchange cane sugar. That’s somebody that nobody has accomplished earlier than. Most sugars don’t behave like cane sugar in meals. They’re too dry, they’re too moist, they’re too onerous, they’re too delicate.”

Finally the buyer merchandise mission resonates extremely for Simmons and his twenty individual group. “We’re going to make use of these massively ample renewable assets produced all around the globe,” he mentioned. 


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